Design and Synthesis of Phthalimide-Based Fluorescent Liver X Receptor Antagonists

Kenji Kishida; Atsushi Aoyama; Yuichi Hashimoto; Hiroyuki Miyachi

doi:10.1248/cpb.58.1525

Notes

Design and Synthesis of Phthalimide-Based Fluorescent Liver X Receptor Antagonists

Kenji Kishida, Atsushi Aoyama, Yuichi Hashimoto, Hiroyuki Miyachi

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Keywords: liver X receptor, liver X receptor antagonist, fluorescent ligand

JOURNAL FREE ACCESS

2010 Volume 58 Issue 11 Pages 1525-1528

DOI https://doi.org/10.1248/cpb.58.1525

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Abstract

Based on our structure–activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.

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