Anticonvulsant Activity and Toxicity Evaluation of CuII and ZnII Metal Complexes Derived from Triazole-Quinoline Ligands

Naveen Vasudev Kulkarni; Srinivasa Budagumpi; Gurunath Suresh Kurdekar; Vidyanand Krishna Revankar; Suresh Didagi

doi:10.1248/cpb.58.1569

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Anticonvulsant Activity and Toxicity Evaluation of Cu^II and Zn^II Metal Complexes Derived from Triazole-Quinoline Ligands

Naveen Vasudev Kulkarni, Srinivasa Budagumpi, Gurunath Suresh Kurdekar, Vidyanand Krishna Revankar, Suresh Didagi

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Keywords: quinoline, triazole, anticonvulsant agent, maximal electroshock method

JOURNAL FREE ACCESS

2010 Volume 58 Issue 12 Pages 1569-1575

DOI https://doi.org/10.1248/cpb.58.1569

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Abstract

A novel Cu^II and Zn^II complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards the electroshock induced seizures in Wistar rats and possesses low toxicity, providing a high safety profile.

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