Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Notes
Cucurbitane Triterpenoids from Momordica charantia and Their Cytoprotective Activity in tert-Butyl Hydroperoxide-Induced Hepatotoxicity of HepG2 Cells
Chiy-Rong ChenYun-Wen LiaoLai WangYueh-Hsiung KuoHung-Jen LiuWen-Ling ShihHsueh-Ling ChengChi-I Chang
Author information
JOURNALS FREE ACCESS

2010 Volume 58 Issue 12 Pages 1639-1642

Details
Abstract

Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.

Information related to the author
© 2010 The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top