Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Two New Asymmetric Sesquiterpene Dimers from the Rhizomes of Ligularia muliensis
Dong-Qing Fei, Qiu-Hong Wu, Shi-Gang Li, Kun Gao
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Keywords: Ligularia muliensis, sesquiterpene dimer, ligulamulienin A, ligulamulienin B, cytotoxic activity
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2010 Volume 58 Issue 4 Pages 467-469

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Abstract
Two new asymmetric eremophilane-type sesquiterpene dimers, ligulamulienin A (1) and B (2), were isolated from the rhizomes of Ligularia muliensis. Their structures were determined based on their spectroscopic data, including IR, EI-MS, HR-electrospray ionization (ESI)-MS, 1D and 2D-NMR spectroscopy. The cytotoxicity of compounds 1 and 2 was measured in in vitro human carcinoma (MGC-803), human hepatoma (HEP-G2), and murine sarcoma (S-180) cell lines.
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© 2010 The Pharmaceutical Society of Japan
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