Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Development of Supramolecular Organo-Gel Based on Tripeptide Skeletons
Eriko AzumaKouji KuramochiKazunori Tsubaki
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2010 Volume 58 Issue 5 Pages 680-684

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Abstract
Boc-Ser-Val-Gly-OCH2Ph (31) showed high gelation abilities in the aromatic solvents, particularly in toluene. The minimum gelation concentration of 31 in toluene was 10 mg/ml, suggesting that 2500 molecules of toluene were immobilized by each molecule of the tripeptide 31. The FT-IR data indicated that formation of antiparallel β-sheets through intermolecular hydrogen bonding was central to the generation of nanofibers during gelation.
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© 2010 The Pharmaceutical Society of Japan
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