α-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of Momordica charantia

Nguyen Xuan Nhiem; Phan Van Kiem; Chau Van Minh; Ninh Khac Ban; Nguyen Xuan Cuong; Nguyen Huu Tung; Le Minh Ha; Do Thi Ha; Bui Huu Tai; Tran Hong Quang; Tran Minh Ngoc; Young-In Kwon; Hae-Dong Jang; Young Ho Kim

doi:10.1248/cpb.58.720

Notes

α-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of Momordica charantia

Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Ninh Khac Ban, Nguyen Xuan Cuong, Nguyen Huu Tung, Le Minh Ha, Do Thi Ha, Bui Huu Tai, Tran Hong Quang, Tran Minh Ngoc, Young-In Kwon, Hae-Dong Jang, Young Ho Kim

Author information

Nguyen Xuan Nhiem
College of Pharmacy, Chungnam National University
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST)
Phan Van Kiem
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST)
Chau Van Minh
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST)
Ninh Khac Ban
Institute of Ecology and Biological Resources, VAST
Nguyen Xuan Cuong
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Huu Tung
College of Pharmacy, Chungnam National University
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST)
Le Minh Ha
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST)
Do Thi Ha
College of Pharmacy, Chungnam National University
Bui Huu Tai
College of Pharmacy, Chungnam National University
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST)
Tran Hong Quang
College of Pharmacy, Chungnam National University
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST)
Tran Minh Ngoc
College of Pharmacy, Chungnam National University
Young-In Kwon
Department of Food and Nutrition, Hannam University
Hae-Dong Jang
Department of Food and Nutrition, Hannam University
Young Ho Kim
College of Pharmacy, Chungnam National University

Keywords: Momordica charantia, Cucurbitaceae, cucurbitane-type triterpene glycoside, charantoside, α-glucosidase

JOURNAL FREE ACCESS

2010 Volume 58 Issue 5 Pages 720-724

DOI https://doi.org/10.1248/cpb.58.720

Details

Abstract

Fourteen cucurbitane-type triterpene glycosides (1—14) were isolated from a methanol extract of Momordica charantia fruits, including three new compounds, charantosides A—C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for α-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against α-glucosidase. Whereas, 2, 3, 6—11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.

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