Phenyl-Substituted Dihydropyrazines with DNA Strand-Breakage Activity

Shigeru Ito; Shinji Takechi; Kazuhide Nakahara; Nobuhiro Kashige; Tadatoshi Yamaguchi

doi:10.1248/cpb.58.825

Regular Articles

Phenyl-Substituted Dihydropyrazines with DNA Strand-Breakage Activity

Shigeru Ito, Shinji Takechi, Kazuhide Nakahara, Nobuhiro Kashige, Tadatoshi Yamaguchi

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Keywords: dihydropyrazine, radical generation, DNA breakage, biological effect, superoxide anion

JOURNAL FREE ACCESS

2010 Volume 58 Issue 6 Pages 825-828

DOI https://doi.org/10.1248/cpb.58.825

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Abstract

Monophenyl-substituted dihydropyrazines (Ph-DHP-1 to 4) of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP-1), which have the inductive effects of apoptosis and mutagenesis, were synthesized and their biological effect was investigated in terms of DNA strand-breakage. Differences between the phenyl- and methyl-substituted dihydropyrazines were examined.

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