Chemical Constituents from the Leaves and Stems of Schisandra lancifolia

Abstract

A new nortriterpenoid, 20-hydroxymicrandilactone D (1) and a novel lignan glycoside, lancilignanside A (2) were isolated from leaves and stems of Schisandra lancifolia, together with three known nortriterpenoids (3—5) and nine known phenolics (6—14). The structures of new compounds 1 and 2 were determined by detailed analysis of their 1D and 2D NMR spectra, and chemical evidences. In addition, compounds 1—2, 6—7, and 9—11 showed anti-human immunodeficiency virus (HIV)-1 activities with 50% effective concentration (EC₅₀) in the range of 3.0—99.0 μg/ml. Compound 12 was not bioactive in this assay with EC₅₀ more than 200 μg/ml.