Oppositinines A and B: New Vasorelaxant β-Carboline Alkaloids from Neisosperma oppositifolia

Kartini Ahmad; Noel F. Thomas; A. Hamid A. Hadi; Mat Ropi Mukhtar; Khalit Mohamad; Mohd Azlan Nafiah; Koichi Takeya; Hiroshi Morita; Marc Litaudon; Hiroko Arai; Khalijah Awang

doi:10.1248/cpb.58.1085

Notes

Oppositinines A and B: New Vasorelaxant β-Carboline Alkaloids from Neisosperma oppositifolia

Kartini Ahmad, Noel F. Thomas, A. Hamid A. Hadi, Mat Ropi Mukhtar, Khalit Mohamad, Mohd Azlan Nafiah, Koichi Takeya, Hiroshi Morita, Marc Litaudon, Hiroko Arai, Khalijah Awang

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Keywords: β-carboline, indole, Neisosperma oppositifolia, Apocynaceae, vasorelaxant activity

JOURNAL FREE ACCESS

2010 Volume 58 Issue 8 Pages 1085-1087

DOI https://doi.org/10.1248/cpb.58.1085

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Abstract

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new β-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 2D NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.

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