9-Azanoradamantane N-Oxyl (Nor-AZADO): A Highly Active Organocatalyst for Alcohol Oxidation

Masaki Hayashi; Yusuke Sasano; Shota Nagasawa; Masatoshi Shibuya; Yoshiharu Iwabuchi

doi:10.1248/cpb.59.1570

Communication to the Editor

9-Azanoradamantane N-Oxyl (Nor-AZADO): A Highly Active Organocatalyst for Alcohol Oxidation

Masaki Hayashi, Yusuke Sasano, Shota Nagasawa, Masatoshi Shibuya, Yoshiharu Iwabuchi

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Keywords: organocatalyst, nitroxyl radical, alcohol oxidation, aerobic oxidation, 2-azaadamantane N-oxyl AZADO

JOURNAL FREE ACCESS

2011 Volume 59 Issue 12 Pages 1570-1573

DOI https://doi.org/10.1248/cpb.59.1570

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Abstract

A highly active organocatalyst for alcohol oxidation has been developed. 9-Azanoradamantane N-oxyl (Nor-AZADO 4), constituting an unhindered, stable nitroxyl radical, exhibits superior catalytic activity to 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and AZADOs in the oxidation of alcohols to their corresponding carbonyl compounds.

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