Xanthone and Benzophenone Glycosides from the Stems of Cratoxylum formosum ssp. pruniflorum

Ying-hui Duan; Yi Dai; Guang-hui Wang; Hai-feng Chen; Hao Gao; Jie-bo Chen; Xin-sheng Yao; Xiao-kun Zhang

doi:10.1248/cpb.59.231

Regular Articles

Xanthone and Benzophenone Glycosides from the Stems of Cratoxylum formosum ssp. pruniflorum

Ying-hui Duan, Yi Dai, Guang-hui Wang, Hai-feng Chen, Hao Gao, Jie-bo Chen, Xin-sheng Yao, Xiao-kun Zhang

Author information

Ying-hui Duan
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
Yi Dai
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
Guang-hui Wang
Institute for Biomedical Research, Xiamen University
Hai-feng Chen
Institute for Biomedical Research, Xiamen University
Hao Gao
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
Jie-bo Chen
Sanford-Burnham Medical Research Institute, Cancer Center
Xin-sheng Yao
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
Xiao-kun Zhang
Institute for Biomedical Research, Xiamen University
Sanford-Burnham Medical Research Institute, Cancer Center

Keywords: Cratoxylum formosum, xanthone, retinoid X receptor α transcriptional activity

JOURNAL FREE ACCESS

2011 Volume 59 Issue 2 Pages 231-234

DOI https://doi.org/10.1248/cpb.59.231

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Abstract

Two new xanthone glycosides, namely pruniflorosides A and B (1, 2), a new benzophenone glycoside, prunifloroside C (3), and a new xanthone, pruniflorone S (4) were isolated from the stems of Cratoxylum formosum ssp. pruniflorum, along with six known xanthones (5—10). Their structures were determined on the basis of extensive spectroscopic analysis. In addition, their retinoid X receptor α (RXRα) transcriptional activities were evaluated in vitro.

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