Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba

Ahmad Kaleem Qureshi; Mat Ropi Mukhtar; Yusuke Hirasawa; Takahiro Hosoya; Alfarius Eko Nugroho; Hiroshi Morita; Osamu Shirota; Khalit Mohamad; A. Hamid A. Hadi; Marc Litaudon; Khalijah Awang

doi:10.1248/cpb.59.291

Notes

Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba

Ahmad Kaleem Qureshi, Mat Ropi Mukhtar, Yusuke Hirasawa, Takahiro Hosoya, Alfarius Eko Nugroho, Hiroshi Morita, Osamu Shirota, Khalit Mohamad, A. Hamid A. Hadi, Marc Litaudon, Khalijah Awang

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Keywords: neolamarckine, indole, Neolamarckia cadamba, Rubiaceae, inducible nitric oxide synthase activity

JOURNAL FREE ACCESS

2011 Volume 59 Issue 2 Pages 291-293

DOI https://doi.org/10.1248/cpb.59.291

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Abstract

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

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