Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba
Ahmad Kaleem QureshiMat Ropi MukhtarYusuke HirasawaTakahiro HosoyaAlfarius Eko NugrohoHiroshi MoritaOsamu ShirotaKhalit MohamadA. Hamid A. HadiMarc LitaudonKhalijah Awang
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2011 Volume 59 Issue 2 Pages 291-293

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Abstract

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

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© 2011 The Pharmaceutical Society of Japan
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