Ceramicines E—I, New Limonoids from Chisocheton ceramicus

Chin Piow Wong; Misae Shimada; Yuta Nagakura; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Khalijah Awang; A. Hamid A. Hadi; Khalit Mohamad; Motoo Shiro; Hiroshi Morita

doi:10.1248/cpb.59.407

Notes

Ceramicines E—I, New Limonoids from Chisocheton ceramicus

Chin Piow Wong, Misae Shimada, Yuta Nagakura, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Khalijah Awang, A. Hamid A. Hadi, Khalit Mohamad, Motoo Shiro, Hiroshi Morita

Author information

Chin Piow Wong
Faculty of Pharmaceutical Sciences, Hoshi University
Misae Shimada
Faculty of Pharmaceutical Sciences, Hoshi University
Yuta Nagakura
Faculty of Pharmaceutical Sciences, Hoshi University
Alfarius Eko Nugroho
Faculty of Pharmaceutical Sciences, Hoshi University
Yusuke Hirasawa
Faculty of Pharmaceutical Sciences, Hoshi University
Toshio Kaneda
Faculty of Pharmaceutical Sciences, Hoshi University
Khalijah Awang
Department of Chemistry, Faculty of Science, University of Malaya
A. Hamid A. Hadi
Department of Chemistry, Faculty of Science, University of Malaya
Khalit Mohamad
Department of Pharmacy, Faculty of Medicine, University Malaya
Motoo Shiro
X-Ray Research Laboratory, Rigaku Corporation
Hiroshi Morita
Faculty of Pharmaceutical Sciences, Hoshi University

Keywords: limonoid, Chisocheton ceramicus, ceramicine, cytotoxic activity

JOURNAL FREE ACCESS

2011 Volume 59 Issue 3 Pages 407-411

DOI https://doi.org/10.1248/cpb.59.407

Details

Abstract

Five new limonoids, ceramicines E—I (1—5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E—I (1—5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis.

Corresponding author

Register with J-STAGE for free!