2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ethers: Their Cytotoxic Activity

Tsutomu Ishikawa; Tatsuru Saito; Ayako Kurosawa; Toshiko Watanabe; Sakiko Maruyama; Yuh-ichiro Ichikawa; Ryota Yamada; Hiroko Okuzawa; Hiromi Sato; Koichi Ueno

doi:10.1248/cpb.59.472

Regular Articles

2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ethers: Their Cytotoxic Activity

Tsutomu Ishikawa, Tatsuru Saito, Ayako Kurosawa, Toshiko Watanabe, Sakiko Maruyama, Yuh-ichiro Ichikawa, Ryota Yamada, Hiroko Okuzawa, Hiromi Sato, Koichi Ueno

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Keywords: 2-aryl-1,4-naphthoquinone-1-oxime methyl ether, benzophenanthridine, cytotoxicity, structure–activity relationship

JOURNAL FREE ACCESS

2011 Volume 59 Issue 4 Pages 472-475

DOI https://doi.org/10.1248/cpb.59.472

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Abstract

Preliminary examination for the structure–activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggested that 2-aryl-6,7-methylenedioxy-1,4-naphthoquinone-1-oxime methyl ethers, carrying 2-methoxy-4,5-methylenedioxyphenyl, 7-methoxy-2-methylbenzofuran-4-yl, and 2-methoxycarbonyl-3,4-dimethoxyphenyl as the 2-aryl substituent, were potential candidates for anti-cancer drugs.

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