Biotransformation of a Taxadiene by Ginkgo Cell Cultures and the Tumor Multi-Drug Resistant Reversal Activities of the Metabolites

Dan Xie; Yi Zhang; Jianhua Zou; Dali Yin; Xiaoguang Chen; Jungui Dai

doi:10.1248/cpb.59.1038

Notes

Biotransformation of a Taxadiene by Ginkgo Cell Cultures and the Tumor Multi-Drug Resistant Reversal Activities of the Metabolites

Dan Xie, Yi Zhang, Jianhua Zou, Dali Yin, Xiaoguang Chen, Jungui Dai

著者情報

キーワード: taxadiene, biotransformation, tumor multi-drug resistant reversal agent, Ginkgo biloba, cell suspension culture

ジャーナルフリー

2011 年 59 巻 8 号 p. 1038-1041

DOI https://doi.org/10.1248/cpb.59.1038

詳細

抄録

The biotransformation of 2α,5α,10β-triacetoxy-14-oxo-taxa-4(20),11-diene (1) by cultured Gingko cells afforded four products. Their structures were identified on the basis of analyses of the chemical and spectroscopic (IR, MS, ¹H- and ¹³C-NMR) data. Among them, 2, 3 and 5 were three new compounds, and 4 displayed potent multi-drug resistant (MDR) reversal activities to MX-1/T tumor MDR cells.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）