Cinchona Alkaloids Are Also Produced by an Endophytic Filamentous Fungus Living in Cinchona Plant

Shoji Maehara; Partomuan Simanjuntak; Chinami Kitamura; Kazuyoshi Ohashi; Hirotaka Shibuya

doi:10.1248/cpb.59.1073

Communications to the Editor

Cinchona Alkaloids Are Also Produced by an Endophytic Filamentous Fungus Living in Cinchona Plant

Shoji Maehara, Partomuan Simanjuntak, Chinami Kitamura, Kazuyoshi Ohashi, Hirotaka Shibuya

Author information

Keywords: Cinchona alkaloid, endophyte, Diaporthe species, Cinchona ledgeriana, bioproduction

JOURNAL FREE ACCESS

2011 Volume 59 Issue 8 Pages 1073-1074

DOI https://doi.org/10.1248/cpb.59.1073

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Abstract

We report that the endophytic filamentous fungus Diaporthe sp., isolated from Cinchona ledgeriana and cultivated in a synthetic liquid medium, produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine). This shows that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in endophytic microbe cells.

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