New 6-Hydroxyeunicellins from a Soft Coral Cladiella sp.

Yung-Husan Chen; Tsong-Long Hwang; Yin-Di Su; Yu-Chia Chang; Yu-Hsin Chen; Pei-Han Hong; Li-Chung Hu; Wei-Hsuan Yen; Hsin-Yin Hsu; Shu-Jung Huang; Yueh-Hsiung Kuo; Ping-Jyun Sung

doi:10.1248/cpb.60.160

Notes

New 6-Hydroxyeunicellins from a Soft Coral Cladiella sp.

Yung-Husan Chen, Tsong-Long Hwang, Yin-Di Su, Yu-Chia Chang, Yu-Hsin Chen, Pei-Han Hong, Li-Chung Hu, Wei-Hsuan Yen, Hsin-Yin Hsu, Shu-Jung Huang, Yueh-Hsiung Kuo, Ping-Jyun Sung

Author information

Yung-Husan Chen
National Museum of Marine Biology and Aquarium, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products, Chang Gung University
Yin-Di Su
National Museum of Marine Biology and Aquarium, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University
Yu-Chia Chang
National Museum of Marine Biology and Aquarium, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica
Yu-Hsin Chen
National Museum of Marine Biology and Aquarium, Taiwan
Department of Life Science and Institute of Biotechnology, National Dong Hwa University
Pei-Han Hong
National Museum of Marine Biology and Aquarium, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University
Li-Chung Hu
National Museum of Marine Biology and Aquarium, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University
Wei-Hsuan Yen
National Museum of Marine Biology and Aquarium, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University
Hsin-Yin Hsu
National Museum of Marine Biology and Aquarium, Taiwan
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University
Shu-Jung Huang
National Museum of Marine Biology and Aquarium, Taiwan
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University
Yueh-Hsiung Kuo
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University
Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University
Ping-Jyun Sung
National Museum of Marine Biology and Aquarium, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University
Department of Life Science and Institute of Biotechnology, National Dong Hwa University
Graduate Institute of Marine Biotechnology, National Dong Hwa University
Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University

Keywords: cladieunicellin, eunicellin, octocoral, Cladiella, superoxide anion, elastase

JOURNAL FREE ACCESS

2012 Volume 60 Issue 1 Pages 160-163

DOI https://doi.org/10.1248/cpb.60.160

Details

Abstract

Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

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