A New Cyclic Tetrapeptide from the Jellyfish-Derived Fungus Phoma sp.

Eun La Kim; Jian Lin Li; Bin Xiao; Jongki Hong; Eun Sook Yoo; Won Duk Yoon; Jee H. Jung

doi:10.1248/cpb.c12-00335

Notes

A New Cyclic Tetrapeptide from the Jellyfish-Derived Fungus Phoma sp.

Eun La Kim, Jian Lin Li, Bin Xiao, Jongki Hong, Eun Sook Yoo, Won Duk Yoon, Jee H. Jung

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Keywords: cyclic tetrapeptide, tentoxin, jellyfish-derived fungus, Phoma sp., Nemopilema nomurai, nitric oxide

JOURNAL FREE ACCESS

2012 Volume 60 Issue 12 Pages 1590-1593

DOI https://doi.org/10.1248/cpb.c12-00335

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Abstract

A new cyclic tetrapeptide (1), along with known congeners (2, 3), was isolated from the fungus Phoma sp. derived from the giant jellyfish Nemopilema nomurai. The absolute configuration of 1 was determined using the modified Mosher’s method and Marfey’s method. Compound 1 displayed a weak suppressive effect on the production of nitric oxide (NO) in murine macrophage cells (RAW264.7) without notable cytotoxicity.

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