Sesquiterpenes and Other Constituents from Dendranthema zawadskii var. latilobum

Hyun Jung Shin; So Young Lee; Ju Sun Kim; Sanghyun Lee; Ran Joo Choi; Ha Sook Chung; Yeong Shik Kim; Sam Sik Kang

doi:10.1248/cpb.60.306

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Sesquiterpenes and Other Constituents from Dendranthema zawadskii var. latilobum

Hyun Jung Shin, So Young Lee, Ju Sun Kim, Sanghyun Lee, Ran Joo Choi, Ha Sook Chung, Yeong Shik Kim, Sam Sik Kang

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Keywords: Dendranthema zawadskii var. latilobum, Asteraceae, germacranolide, eudesmane glucoside, nitric oxide inhibition

JOURNAL FREE ACCESS

2012 Volume 60 Issue 3 Pages 306-314

DOI https://doi.org/10.1248/cpb.60.306

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Abstract

Six new germacranolides, zawadskinolides A—F (1—6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. latilobum, along with thirteen known constituents. Their structures were elucidated by means of spectroscopic evidence. Bioassay showed that flavonoids such as apigenin (9), (−)-eriodictyol (10) and nepetin (12), as well as the sesquiterpene lactone, zawadskinolide F (6), inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC₅₀ values of 66.15, 132.55, 35.44, and 91.32 μM, respectively.

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