Monoterpene Glucosides from Ziziphora clinopodioides (Labiatae)

Megumi Furukawa; Naoki Oikawa; Toru Imohata; Mitsuko Makino; Shoujiro Ogawa; Takashi Iida; Yasuo Fujimoto; Susumu Kitanaka

doi:10.1248/cpb.60.397

Notes

Monoterpene Glucosides from Ziziphora clinopodioides (Labiatae)

Megumi Furukawa, Naoki Oikawa, Toru Imohata, Mitsuko Makino, Shoujiro Ogawa, Takashi Iida, Yasuo Fujimoto, Susumu Kitanaka

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Keywords: Labiatae, Ziziphora clinopodioides, monoterpene glucoside, nitric oxide, macrophage

JOURNAL FREE ACCESS

2012 Volume 60 Issue 3 Pages 397-401

DOI https://doi.org/10.1248/cpb.60.397

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Abstract

Three new monoterpene glucosides, ziziphoroside A (1), B (2), and C (3), together with fifteen known compounds were isolated from the whole herb of Z. clinopodioides. The structures of new compounds were determined primarily from 1D-, 2D-NMR and circular dichroism (CD) spectroscopic analyses. The isolated compounds were evaluated for their inhibitory activity against nitric oxide (NO) production by lipopolysaccharide (LPS) and interferon (IFN)-γ activated macrophages, RAW 264.7. Shizonepetoside A (8) and flavones (11, 12, 13) showed potent inhibitory activity against NO production.

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