Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agricultural University Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University
Min Yu
Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agricultural University
Qiao-Hong Chen
Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University
Feng-Peng Wang
Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University
Published: March 01, 2012Received: November 20, 2011Available on J-STAGE: March 01, 2012Accepted: December 12, 2011
Advance online publication: -
Revised: -
A selective intramolecular transacylation from C-4 to C-5 of taxoids, which occurred simultaneously with the oxetane D-ring opening and was promoted by TiCl4, was presented. The optimal condition was found to be treatment of substrates in double dose of dichloromethane (per mg of substrate dissolved in 2 mL DCM) with 1 eq of TiCl4 at 25°C for 10 min.
