Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Stereoselective Total Synthesis of Atpenins A4 and B, Harzianopyridone, and NBRI23477 B
Masaki OhtawaKouhei SugiyamaTohru HiuraShujiro IzawaKazuro ShiomiSatoshi OmuraTohru Nagamitsu
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2012 Volume 60 Issue 7 Pages 898-906

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Abstract

The stereoselective total synthesis of atpenins A4 (2) and B (3), harzianopyridone (4), and NBRI23477 B (5) have been developed using a convergent approach involving the coupling reaction of a common iodopyridine with an aldehyde corresponding to the appropriate side chain of the desired compound. Furthermore, the absolute configurations of atpenin B (3), harzianopyridone (4), and NBRI23477 B (5) have been unambiguously determined.

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© 2012 The Pharmaceutical Society of Japan
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