Synthesis and Pharmacological Profile of a New Selective G Protein-Coupled Receptor 119 Agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one

Masao Sakairi; Masakazu Kogami; Masafumi Torii; Mitsuhiro Makino; Daisuke Kataoka; Ryuji Okamoto; Toshiyuki Miyazawa; Megumi Inoue; Naoki Takahashi; Satoko Harada; Nobuhide Watanabe

doi:10.1248/cpb.c12-00484

Communication to the Editor

Synthesis and Pharmacological Profile of a New Selective G Protein-Coupled Receptor 119 Agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one

Masao Sakairi, Masakazu Kogami, Masafumi Torii, Mitsuhiro Makino, Daisuke Kataoka, Ryuji Okamoto, Toshiyuki Miyazawa, Megumi Inoue, Naoki Takahashi, Satoko Harada, Nobuhide Watanabe

Author information

Masao Sakairi
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Masakazu Kogami
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Masafumi Torii
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Mitsuhiro Makino
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Daisuke Kataoka
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Ryuji Okamoto
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Toshiyuki Miyazawa
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Megumi Inoue
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Naoki Takahashi
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Satoko Harada
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
Nobuhide Watanabe
Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.

Keywords: glucagon-like peptide-1, G protein-coupled receptor 119 agonist, glucose-dependent insulin secretagogue, gastric emptying

JOURNAL FREE ACCESS

2012 Volume 60 Issue 9 Pages 1093-1095

DOI https://doi.org/10.1248/cpb.c12-00484

Details

Abstract

6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists.

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