Improved Preparation of Methyl Bis(2,2,2-trifluoroethoxy)-bromophosphonoacetate for the Stereoselective Synthesis of (E)-α-Bromoacrylates

Akiko Nakata; Kenichi Kobayashi; Hiroshi Kogen

doi:10.1248/cpb.c12-00808

Notes

Improved Preparation of Methyl Bis(2,2,2-trifluoroethoxy)-bromophosphonoacetate for the Stereoselective Synthesis of (E)-α-Bromoacrylates

Akiko Nakata, Kenichi Kobayashi, Hiroshi Kogen

Author information

Keywords: (E)-α-bromoacrylate, Horner–Wadsworth–Emmons reaction, stereoselective synthesis, bis(2,2,2-trifluoroethoxy)bromophosphonoacetate

JOURNAL FREE ACCESS

2013 Volume 61 Issue 1 Pages 108-110

DOI https://doi.org/10.1248/cpb.c12-00808

Browse “Advance online publication” version

Details

Abstract

We have established an efficient method for preparing methyl bis(2,2,2-trifluoroethoxy)bromophosphonoacetate, which we developed for the stereoselective synthesis of (E)-α-bromoacrylates. This improved method enables the reagent to be prepared reproducibly in one step from methyl bis(2,2,2-trifluoroethoxy)phosphonoacetate.

Corresponding author

Register with J-STAGE for free!