Inhibitory Effect of Four Triterpenoids from Trichilia connaroides on Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW264.7 Cells

Hong-Ying Wang; Jun-Song Wang; Yao Zhang; Jun Luo; Ming-Hua Yang; Xiao-Bing Wang; Ling-Yi Kong

doi:10.1248/cpb.c13-00286

Notes

Inhibitory Effect of Four Triterpenoids from Trichilia connaroides on Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW264.7 Cells

Hong-Ying Wang, Jun-Song Wang, Yao Zhang, Jun Luo, Ming-Hua Yang, Xiao-Bing Wang, Ling-Yi Kong

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Keywords: Trichilia connaroides, Meliaceae, triterpenoid, nitric oxide production inhibition

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Supplementary material

2013 Volume 61 Issue 10 Pages 1075-1080

DOI https://doi.org/10.1248/cpb.c13-00286

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Abstract

Two new highly rearranged trichiliton-type limonoids (trichilitons G–H, 1–2), and two new cycloartane-type triterpenoids, 21-(E)-coumaroyloxy-5α-cycloart-24-ene-3,23-dione (3) and 21-(E)-feruloyloxy-5α-cycloart-24-ene-3,23-dione (4), were isolated from the stem and bark of Trichilia connaroides. These isolates were elucidated on the basis of detailed spectroscopic analysis, and inhibitory effect of these compounds on lipopolysaccharide-induced nitric oxide production in mouse macrophage RAW264.7 cells was evaluated.

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