Antibacterial Activity of Some 5-Dialkylaminomethylhydantoins and Related Derivatives

Fumiko Fujisaki; Keiko Toyofuku; Mayu Egami; Shiori Ishida; Naho Nakamoto; Nobuhiro Kashige; Fumio Miake; Kunihiro Sumoto

doi:10.1248/cpb.c13-00461

Notes

Antibacterial Activity of Some 5-Dialkylaminomethylhydantoins and Related Derivatives

Fumiko Fujisaki, Keiko Toyofuku, Mayu Egami, Shiori Ishida, Naho Nakamoto, Nobuhiro Kashige, Fumio Miake, Kunihiro Sumoto

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Keywords: hydantoin, antibacterial activity, C₂-symmetrical twin-drug, Escherichia coli, Staphylococcus aureus, β-aminoalanine

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2013 Volume 61 Issue 10 Pages 1090-1093

DOI https://doi.org/10.1248/cpb.c13-00461

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Abstract

In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C₂-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity against S. aureus strain.

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