Synthesis and Antioxidant Activity of Styrylsulfonylmethyl 1,3,4-Oxadiazoles, Pyrazolyl/Isoxazolyl-1,3,4-oxadiazoles

Guda Mallikarjuna Reddy; Akkarapalli Muralikrishna; Venkatapuram Padmavathi; Adivireddy Padmaja; Thandaiah Krishna Tilak; Chippada Appa Rao

doi:10.1248/cpb.c13-00652

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Synthesis and Antioxidant Activity of Styrylsulfonylmethyl 1,3,4-Oxadiazoles, Pyrazolyl/Isoxazolyl-1,3,4-oxadiazoles

Guda Mallikarjuna Reddy, Akkarapalli Muralikrishna, Venkatapuram Padmavathi, Adivireddy Padmaja , Thandaiah Krishna Tilak, Chippada Appa Rao

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Keywords: pyrazolyl, isoxazolyl oxadiazole, nitrile imine, nitrile oxide, antioxidant activity

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2013 Volume 61 Issue 12 Pages 1291-1297

DOI https://doi.org/10.1248/cpb.c13-00652

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Abstract

A new class of mono and bis heterocycles-styrylsulfonylmethyl 1,3,4-oxadiazoles, pyrazolyl/isoxazolyl-1,3,4-oxadiazoles were prepared and studied their antioxidant activity. The compound methyl substituted 2-(p-methylphenylamino-sulfonylmethyl)-5-[Z-(p-methylstyrylsulfonylmethyl)]-1,3,4-oxadiazole displayed slightly higher antioxidant activity than the standard ascorbic acid.

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