Triterpene Saponins from Clethra barbinervis and Their Hyaluronidase Inhibitory Activities

Abstract

An extract of Clethra barbinervis with an inhibitory effect on hyaluronidase activity was fractionated guided by the results of an assay. From the active fractions, seven new triterpene saponins (1–4, 6–8) and a new lignan glycoside (14) were isolated together with 14 known compounds (5, 9–13, 15–22). Some of the saponins (2, 3, 9) were revealed as hyaluronidase inhibitors similar to epicatechin (17).