Lasiodiplodin Analogues from the Endophytic Fungus Sarocladium kiliense

Wei Hua Yuan; Nan Jiang; Cai Hong Dong; Zhi Wen Wei; Han Kui Wu; Cai Fa Chen; Yan Xia Zhao; Sheng Liang Zhou; Mei Mei Zhang; Wei Fa Zheng

doi:10.1248/cpb.c12-00898

Notes

Lasiodiplodin Analogues from the Endophytic Fungus Sarocladium kiliense

Wei Hua Yuan, Nan Jiang, Cai Hong Dong, Zhi Wen Wei, Han Kui Wu, Cai Fa Chen, Yan Xia Zhao, Sheng Liang Zhou, Mei Mei Zhang, Wei Fa Zheng

Author information

Wei Hua Yuan
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University
Nan Jiang
Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University
Cai Hong Dong
Institute of microbiology Chinese Academy of Sciences
Zhi Wen Wei
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University
Han Kui Wu
College of Chemistry and Chemical Engineering, Anyang Normal University
Cai Fa Chen
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University
Yan Xia Zhao
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University
Sheng Liang Zhou
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University
Mei Mei Zhang
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University
Wei Fa Zheng
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University

Keywords: endophytic fungus, natural product, X-ray diffraction, Mosher’s method

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Supplementary material

2013 Volume 61 Issue 3 Pages 363-365

DOI https://doi.org/10.1248/cpb.c12-00898

Details

Abstract

A new 12-membered ring lactone, (3S),(6R)-6-hydroxylasiodiplodin (1), with two known analogues, (3R)-lasiodiplodin (2), and (3R),(5S)-5-hydroxylasiodiplodin (3) were isolated from the EtOH extracts of normal Apriona germari (Hope)-associated fungus Sarocladium kiliense grown in rice medium. The structures of compounds 1–3 were elucidated by a combination of spectroscopic data interpretation, single-crystal X-ray diffraction analysis, and modified Mosher’s method.

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