Nakijiquinone S and Nakijinol C, New Meroterpenoids from a Marine Sponge of the Family Spongiidae

Haruna Suzuki; Takaaki Kubota; Azusa Takahashi-Nakaguchi; Jane Fromont; Tohru Gonoi; Jun’ichi Kobayashi

doi:10.1248/cpb.c13-00810

Notes

Nakijiquinone S and Nakijinol C, New Meroterpenoids from a Marine Sponge of the Family Spongiidae

Haruna Suzuki, Takaaki Kubota, Azusa Takahashi-Nakaguchi, Jane Fromont, Tohru Gonoi, Jun’ichi Kobayashi

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Keywords: marine sponge, Spongiidae, meroterpenoid, nakijiquinone S, nakijinol C, antimicrobial activity

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2014 Volume 62 Issue 2 Pages 209-212

DOI https://doi.org/10.1248/cpb.c13-00810

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Abstract

New meroterpenoids, nakijiquinone S (1) and nakijinol C (2), have been isolated from an Okinawan marine sponge of the family Spongiidae. The gross structures and relative stereochemistries of 1 and 2 were elucidated on the basis of their spectral data. Nakijiquinone S (1) and nakijinol C (2) were new meroterpenoids consisting of a clerodane-type decalin ring connected to a 2-butoxy-5-hydroxy-benzoquinone unit or methyl 2,3,4-trihydroxybenzoate unit through a methylene, respectively. Nakijiquinone S (1) and nakijinol C (2) showed antimicrobial activities against several bacteria and fungi.

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