Synthesis of 1-(4-Aminobutyl)-2-iminoimidazolidin-4-one Aimed at Preparation of a Creatinine-Specific Antibody

Shun-suke Moriya; Naoki Terayama; Kyoko Hiramatsu; Masao Kawakita; Tatsuya Kiryu; Takato Kawanishi; Eiko Yasui; Shinji Nagumo

doi:10.1248/cpb.c13-00960

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Synthesis of 1-(4-Aminobutyl)-2-iminoimidazolidin-4-one Aimed at Preparation of a Creatinine-Specific Antibody

Shun-suke Moriya, Naoki Terayama, Kyoko Hiramatsu, Masao Kawakita, Tatsuya Kiryu, Takato Kawanishi, Eiko Yasui, Shinji Nagumo

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Keywords: creatinine derivative, synthesis, guanidinylation, anti-creatinine immunoglobulin

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2014 Volume 62 Issue 4 Pages 350-353

DOI https://doi.org/10.1248/cpb.c13-00960

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Abstract

For the purpose of obtaining a creatinine-specific antibody, a creatinine derivative with 4-aminobutyl, which was served as a linker for preparing the creatinine–bovine serum albumin (BSA) conjugate, was synthesized from 4-benzylaminobutan-1-ol in 8 steps. Production of anti-creatinine antibodies was observed in two rabbits using the creatinine–BSA conjugate, although their titer was rather low.

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