Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Teucvisins A–E, Five New neo-Clerodane Diterpenes from Teucrium viscidum
Hua-wei LvJian-guang LuoMeng-di ZhuSi-ming ShanLing-yi Kong
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Supplementary material

2014 Volume 62 Issue 5 Pages 472-476

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Abstract
Two new neo-clerodane diterpenoids, teucvisins A and B (1, 2), and three new 19-nor-neoclerodane diterpenoids, teucvisins C–E (35), together with ten known constituents (615) were isolated from the whole plants of Teucrium viscidum. All the isolates were evaluated for their inhibitory activities of lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages. The results indicated that compounds 11 and 15 showed moderate inhibition with an IC50 value of 21.9 and 22.4 µM, respectively.
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© 2014 The Pharmaceutical Society of Japan
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