Improved Synthetic Route to Methyl 1-Fluoroindan-1-carboxylate (FICA Me Ester) and 4-Methyl Derivatives

Jyunichi Koyanagi; Tomoyo Kamei; Miyuki Ishizaki; Hiroshi Nakamura; Tamiko Takahashi

doi:10.1248/cpb.c14-00192

Notes

Improved Synthetic Route to Methyl 1-Fluoroindan-1-carboxylate (FICA Me Ester) and 4-Methyl Derivatives

Jyunichi Koyanagi, Tomoyo Kamei, Miyuki Ishizaki, Hiroshi Nakamura, Tamiko Takahashi

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Keywords: chiral derivatizing agent, methyl 1-fluoroindan-1-carboxylate, fluorination

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2014 Volume 62 Issue 8 Pages 816-819

DOI https://doi.org/10.1248/cpb.c14-00192

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Abstract

An improved synthetic route has been developed for the preparation of methyl 1-fluoroindan-1-carboxylate (FICA Me ester) from 1-indanone. Methyl 4-methyl-1-fluoroindan-1-carboxylate (4-Me-FICA Me ester) was also prepared following the same procedure.

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