Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Novel Dammarane-Type Triterpene Saponins from Panax ginseng Root
Dong Gu LeeAh Young LeeKyung-Tack KimEun Ju ChoSanghyun Lee
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2015 Volume 63 Issue 11 Pages 927-934

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Abstract

Four phytochemical constituents were isolated from Panax ginseng root by repeated column chromatography (CC), medium pressure liquid chromatography (MPLC), high-speed counter current chromatography (HSCCC), and semi-preparative HPLC. Their structures were elucidated as the dammarane-type triterpene saponins ginsenoside-Rg18 (1), 6-acetyl ginsenoside-Rg3 (2), ginsenoside-Rs11 (3), and ginsenoside-Re7 (4) based on spectral data. Compounds 14 from P. ginseng root were new compounds from nature. They showed good hydroxyl radical scavenging activity and anti-bacterial activity against Escherichia coli and Staphylococcus aureus. However, they did not show any anti-inflammatory activity. In addition, they inhibited the growth of adenocarcinoma gastric stomach cells. Among them, ginsenoside-Rs11 (3) showed the best anti-oxidative, anti-bacterial, and anti-cancer activities.

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© 2015 The Pharmaceutical Society of Japan
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