New Glabretal Triterpenes from the Immature Fruits of Poncirus trifoliata and Their Selective Cytotoxicity

Ae-Ran Choi; In-Kyoung Lee; E-Eum Woo; Jin-Won Kwon; Bong-Sik Yun; Hae-Ryong Park

doi:10.1248/cpb.c15-00465

Notes

New Glabretal Triterpenes from the Immature Fruits of Poncirus trifoliata and Their Selective Cytotoxicity

Ae-Ran Choi, In-Kyoung Lee, E-Eum Woo, Jin-Won Kwon, Bong-Sik Yun , Hae-Ryong Park

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Keywords: Poncirus trifoliata, pancastatin, glabretal triterpene, selective cytotoxicity

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Supplementary material

2015 Volume 63 Issue 12 Pages 1065-1069

DOI https://doi.org/10.1248/cpb.c15-00465

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Abstract

Two new glabretal triterpenes, pancastatins A (1) and B (2), were isolated from the immature fruits of Poncirus trifoliata. Their chemical structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR and high-resolution electrospray ionization mass spectrometry. Compounds 1 and 2 exhibited selective cytotoxicity against PANC-1 pancreatic cancer cells under low-glucose stress conditions.

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