Effect of Chaenomeles sinensis Extract on Choline Acetyltransferase Activity and Trimethyltin-Induced Learning and Memory Impairment in Mice

Yoon Kyung Kwon; Soo Jung Choi; Cho Rong Kim; Jae Kyeom Kim; Hye Kyung Kim; Jong Hun Choi; Sang-Wook Song; Chang-Ju Kim; Gwi Gun Park; Cheung-Seog Park; Dong-Hoon Shin

doi:10.1248/cpb.c15-00559

Notes

Effect of Chaenomeles sinensis Extract on Choline Acetyltransferase Activity and Trimethyltin-Induced Learning and Memory Impairment in Mice

Yoon Kyung Kwon, Soo Jung Choi, Cho Rong Kim, Jae Kyeom Kim, Hye Kyung Kim, Jong Hun Choi, Sang-Wook Song, Chang-Ju Kim, Gwi Gun Park, Cheung-Seog Park, Dong-Hoon Shin

Author information

Yoon Kyung Kwon
Department of Food and Biotechnology, Korea University
Soo Jung Choi
Functional Food Research Center, Korea University
Cho Rong Kim
Functional Food Research Center, Korea University
Jae Kyeom Kim
Department of Food Science and Nutrition, University of Minnesota
Hye Kyung Kim
Department of Food and Biotechnology, Hanseo University
Jong Hun Choi
Natural Way Co., Ltd.
Sang-Wook Song
Department of Family Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea
Chang-Ju Kim
Department of Physiology, Kyung Hee University
Gwi Gun Park
Department of Food Science and Biotechnology, GaChon University
Cheung-Seog Park
Department of Microbiology, School of Medicine, Kyung Hee University
Dong-Hoon Shin Corresponding author
Department of Food and Biotechnology, Korea University

Keywords: Chaenomeles sinensis, learning, memory, cognitive impairment, stearic acid methyl ester, choline acetyltransferase

JOURNAL FREE ACCESS FULL-TEXT HTML

2015 Volume 63 Issue 12 Pages 1076-1080

DOI https://doi.org/10.1248/cpb.c15-00559

Details

Abstract

The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis Koehne showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [¹⁴C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer’s disease.

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