Geranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production

抄録

The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3′-O-methyl-5′-hydroxydiplacol (1), along with 10 known compounds (2–11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1–6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC₅₀ values ranging 1.48 to 16.66 µM.