New Iridoid Glycosides with Antidepressant Activity Isolated from Cyperus rotundus

Zhong-liu Zhou; Wen-Qing Yin; Ya-Mei Yang; Chun-Hong He; Xiao-Na Li; Cui-Ping Zhou; Hong Guo

doi:10.1248/cpb.c15-00686

Notes

New Iridoid Glycosides with Antidepressant Activity Isolated from Cyperus rotundus

Zhong-liu Zhou , Wen-Qing Yin, Ya-Mei Yang, Chun-Hong He, Xiao-Na Li, Cui-Ping Zhou, Hong Guo

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Keywords: Cyperus rotundus, rotunduside G, rotunduside H, antidepressant

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2016 Volume 64 Issue 1 Pages 73-77

DOI https://doi.org/10.1248/cpb.c15-00686

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Abstract

Based on bioactive screening results, two new iridoid glycosides, named rotunduside G (1) and rotunduside H (2), were isolated from the rhizomes of Cyperus rotundus, together with four known ones, negundoside (3), nishindaside (4), isooleuropein (5) and neonuezhenide (6). Their structures were elucidated on the basis of spectroscopic methods and from literature values. In mice models of despair, 1 and 2 showed significant antidepressant activity.

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