Asymmetric Chlorination of β-Keto Esters Using Diaminomethylenemalononitrile Organocatalyst

Takaaki Sakai; Shin-ichi Hirashima; Kosuke Nakashima; Chie Maeda; Akihiro Yoshida; Yuji Koseki; Tsuyoshi Miura

doi:10.1248/cpb.c16-00722

Notes

Asymmetric Chlorination of β-Keto Esters Using Diaminomethylenemalononitrile Organocatalyst

Takaaki Sakai, Shin-ichi Hirashima, Kosuke Nakashima, Chie Maeda, Akihiro Yoshida, Yuji Koseki, Tsuyoshi Miura

著者情報

キーワード: organocatalyst, asymmetric chlorination, β-keto ester

ジャーナルフリー HTML

2016 年 64 巻 12 号 p. 1781-1784

DOI https://doi.org/10.1248/cpb.c16-00722

詳細

抄録

Diaminomethylenemalononitrile organocatalysts promote the asymmetric chlorination of simple cyclic β-keto esters such as methyl, ethyl, and benzyl esters of 1-oxo-2,3-dihydro-1H-indene-2-carboxylic acid. This affords the corresponding chiral α-chlorinated carbonyl products in excellent yields with high enantioselectivities.

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