Inflammatory Inhibitory Activity of Sesquiterpenoids from Atractylodes macrocephala Rhizomes

Abstract

Three new sesquiterpenoids, 13-hydroxyl-atractylenolide II (1), 4-ketone-atractylenolide III (2), and eudesm-4(15)-ene-7β,11-diol (3), along with eleven known compounds (4–14), were isolated from the rhizomes of Atractylodes macrocephala. The structures and relative configurations of 1–3 were determined by analysis of the spectroscopic data, and the absolute configurations of 1 and 2 were assigned by circular dichroism technique. The anti-inflammatory activities of these isolates were evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cells; compounds 4, 7, and 8 exhibited moderate efficacy with IC₅₀ values of 48.6±0.5, 46.4±3.2, and 32.3±2.9 µM, respectively.

Graphical Abstract