Use of Phthalimidoacetyl Isothiocyanate as a Scaffold in the Synthesis of Target Heterocyclic Systems, and Their Antimicrobial Assessment

Magdy Mohamed Hemdan; Amira Abd-Elhaleem El-Sayed

doi:10.1248/cpb.c16-00099

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Use of Phthalimidoacetyl Isothiocyanate as a Scaffold in the Synthesis of Target Heterocyclic Systems, and Their Antimicrobial Assessment

Magdy Mohamed Hemdan , Amira Abd-Elhaleem El-Sayed

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Keywords: phthalimidoacetyl isothiocyanate, 1,2,4-triazol, 1,3-diazine, 1,3-oxazine, thiourea, antimicrobial

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2016 Volume 64 Issue 5 Pages 483-489

DOI https://doi.org/10.1248/cpb.c16-00099

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Abstract

Phthalimidoacetyl isothiocyanate underwent addition-cyclization reactions with some nitrogen and carbon nucleophilic reagents. Simultaneous or subsequent cyclization of the obtained adducts gave target heterocyclic systems such as 1,2,4-triazoles, 1,3-diazines, 1,3-oxazines and thiourea attached to a phthalimido moiety. The antimicrobial activity of the synthesized compounds was tested.

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