Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Sesquiterpenoids from the Rhizomes of Curcuma phaeocaulis and Their Inhibitory Effects on LPS-Induced TLR4 Activation
Hyun-Jae Jang, Jin-Han Kim, Hyun-Mee Oh, Min-Suk Kim, Jin Ha Jo, Kyungsook Jung, Soyoung Lee, Young-Ho Kim, Woo Song Lee, Seung Woong Lee , Mun-Chual Rho
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Keywords: Curcuma phaeocaulis, Zingiberaceae, sesquiterpenoid, Toll-like receptor 4 (TLR4), lipopolysaccharide (LPS)
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2016 Volume 64 Issue 7 Pages 1062-1066

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Abstract
Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.
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© 2016 The Pharmaceutical Society of Japan
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