Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Special Collection of Papers: Regular Articles
Enantioselective Total Synthesis of the Proposed Structure of Furan-Containing Polyketide
Hideki AbeSatoko ItayaKei SasakiToyoharu KobayashiHisanaka Ito
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2016 Volume 64 Issue 7 Pages 772-777

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Abstract

Enantioselective total synthesis of the proposed structure of furan-containing polyketide was accomplished. The key features include a chemo- and enantioselective epoxidation of 1,4-cyclohexadiene by Shi asymmetric epoxidation, a regioselective epoxide ring opening, chemo- and diastereoselective dihydroxylation of the conjugated dienone derivative, and vinylation of the lactone accompanied by formation of the furan ring.

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© 2016 The Pharmaceutical Society of Japan
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