Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Special Collection of Papers: Notes
Antimalarial Phenanthroindolizine Alkaloids from Ficus septica
Miwa KuboWataru YatsuzukaShoko MatsushimaKenichi HaradaYusuke InoueHisashi MiyamotoMakoto MatsumotoYoshiyasu Fukuyama
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2016 Volume 64 Issue 7 Pages 957-960

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Abstract

During the screening of antimalarial substances, MeOH extract from the twigs of Ficus septica was shown to have potent antimalarial activity. Bioassay-guided fractionation of a methanol extract of the twigs of F. septica led to the isolation of a new seco-phenanthroindolizine alkaloid and three known phenanthroindolizine alkaloids. Their structures were elucidated on the basis of NMR analysis. All isolated compounds were tested against Plasmodium falciparum. Compounds 24 displayed antimalarial activity against the 3D7 strain of P. falciparum with IC50 values 0.028–0.42 µM, whereas a new compound 1 exhibited a moderate antimalarial activity.

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© 2016 The Pharmaceutical Society of Japan
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