Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Special Collection of Papers: Notes
Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to κ-Opioid Receptor
Daisuke NishiyamaYuki SakaiHaruka SekiguchiHiroaki ChibaRyosuke MisuShinya OishiNobutaka FujiiHiroaki Ohno
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2016 Volume 64 Issue 7 Pages 996-1003

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Abstract

A series of novel 3,4,7-trisubstituted benzofuran derivatives were synthesized, and their binding affinity to κ- (KOR) and μ-opioid receptors (MOR) were evaluated. Several aryl ethers showed moderate binding activities to KOR (IC50=3.9–11 µM) without binding to MOR.

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© 2016 The Pharmaceutical Society of Japan
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