Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Improved Synthesis of Nigricanin
Hitoshi Abe Takanori NagaiHaruka ImaiYoshikazu Horino
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2017 Volume 65 Issue 11 Pages 1078-1080

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Abstract

An ellagic acid-related natural product, nigricanin (1), was synthesized via the Ullmann coupling reaction of 2-bromo-3,4-dialkoxybenzaldehyde (4) followed by the Cannizzaro reaction for desymmetrization of the symmetric biaryl compound (5). Compared to our previously reported study, the presented synthesis improved the sequence step number.

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© 2017 The Pharmaceutical Society of Japan
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