Asymmetric Conjugate Additions of Carbonyl Compounds to Nitroalkenes under Solvent-Free Conditions Using Fluorous Diaminomethylenemalononitrile Organocatalyst

Shin-ichi Hirashima; Takafumi Narushima; Masahiro Kawada; Kosuke Nakashima; Kaori Hanai; Yuji Koseki; Tsuyoshi Miura

doi:10.1248/cpb.c17-00596

Notes

Asymmetric Conjugate Additions of Carbonyl Compounds to Nitroalkenes under Solvent-Free Conditions Using Fluorous Diaminomethylenemalononitrile Organocatalyst

Shin-ichi Hirashima, Takafumi Narushima, Masahiro Kawada, Kosuke Nakashima, Kaori Hanai, Yuji Koseki, Tsuyoshi Miura

著者情報

キーワード: organocatalyst, fluorous, conjugate addition, solvent-free

ジャーナルフリー HTML

2017 年 65 巻 12 号 p. 1185-1190

DOI https://doi.org/10.1248/cpb.c17-00596

詳細

抄録

The novel fluorous organocatalyst bearing a diaminomethylenemalononitrile motif is prepared. The fluorous organocatalyst efficiently promotes asymmetric conjugate additions of ketones to nitroalkenes and results in high yields of these addition products with excellent enantioselectivities under solvent-free conditions.

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