Chemical Synthetic Platform for Chlorpromazine Oligomers That Were Reported as Photo-degradation Products of Chlorpromazine

Taiki Kohiki; Yusuke Nishikawa; Tsubasa Inokuma; Akira Shigenaga; Akira Otaka

doi:10.1248/cpb.c17-00692

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Chemical Synthetic Platform for Chlorpromazine Oligomers That Were Reported as Photo-degradation Products of Chlorpromazine

Taiki Kohiki, Yusuke Nishikawa, Tsubasa Inokuma, Akira Shigenaga , Akira Otaka

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Keywords: chlorpromazine (CPZ), chlorpromazine dimer, chlorpromazine trimer, chlorpromazine oligomer, photo-reaction, photosensitization

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2017 Volume 65 Issue 12 Pages 1161-1166

DOI https://doi.org/10.1248/cpb.c17-00692

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Abstract

A synthetic platform for chlorpromazine (CPZ) oligomers, which could be generated via photo-reaction of CPZ, is essential to promote their biological and structural studies. In this paper, the first synthetic platform for CPZ oligomers is described. A photo-irradiation experiment of CPZ to confirm whether the structure of the CPZ dimer generated by the photo-irradiation was identical to that prepared by our synthetic method is also reported.

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