Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta

Ninh Thi Ngoc; Pham Thi Mai Huong; Nguyen Van Thanh; Nguyen Thi Phuong Chi; Nguyen Hai Dang; Nguyen Xuan Cuong; Nguyen Hoai Nam; Do Cong Thung; Phan Van Kiem; Chau Van Minh

doi:10.1248/cpb.c16-00881

Regular Articles

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta

Ninh Thi Ngoc, Pham Thi Mai Huong, Nguyen Van Thanh, Nguyen Thi Phuong Chi, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh

Author information

Ninh Thi Ngoc
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Graduate University of Science and Technology, VAST
Pham Thi Mai Huong
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Van Thanh
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Thi Phuong Chi
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Hai Dang
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Xuan Cuong
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Hoai Nam
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Do Cong Thung
Institute of Marine Environment and Resources, VAST
Phan Van Kiem
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Chau Van Minh Corresponding author
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

Keywords: Sinularia conferta, Alcyoniidae, soft coral, steroid, cytotoxic activity

JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary material

2017 Volume 65 Issue 3 Pages 300-305

DOI https://doi.org/10.1248/cpb.c16-00881

Browse “Advance online publication” version

Details

Abstract

Twelve steroids, including five new compounds 1–5, were isolated and structurally elucidated from a methanol extract of the Vietnamese soft coral Sinularia conferta. Their cytotoxic effects against three human cancer cell lines, lung carcinoma (A-549), cervical adenocarcinoma (HeLa), and pancreatic epithelioid carcinoma (PANC-1), were evaluated using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assays. Among isolated compounds, 10 exhibited potent cytotoxic effects on all three tested cell lines with IC₅₀ values of 3.64±0.18, 19.34±0.42, and 1.78±0.69 µM, respectively.

Graphical Abstract Fullsize Image

Corresponding author

Register with J-STAGE for free!