J-STAGE Home  >  Publications - Top  > Bibliographic Information

Chemical and Pharmaceutical Bulletin
Vol. 65 (2017) No. 4 p. 356-358

Language:

http://doi.org/10.1248/cpb.c17-00054

Communications to the Editor

Red-shifted channelrhodopsins (ChRs) are attractive for optogenetic tools. We developed a new type of red-shifted ChRs that utilized noncovalent incorporation of retinal and 3,4-dehydroretinal-based enamine-type Schiff bases and mutated channelopsin, C1C2-K296G. These ChRs exhibited absorption maxima that were shifted 10–30 nm toward longer wavelengths than that of C1C2-ChR regenerated with all-trans-retinal.

Graphical Abstract Fullsize Image

Copyright © 2017 The Pharmaceutical Society of Japan

Article Tools

  • Add to Favorites
  • Citation Alert
  • Authentication Alert
  • Additional Info Alert
  • Copy the URL
  • Download Meta of Article
  • RIS
  • BibTeX
  • [ Help ]
  • Contact us

Share this Article