Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Communications to the Editor
Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin
Takashi OkitsuTake MatsuyamaTakahiro YamashitaToru IshizukaHiromu YawoYasushi ImamotoYoshinori ShichidaAkimori Wada
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

Volume 65 (2017) Issue 4 Pages 356-358

Details
Full Text-HTML Download PDF (1118K) Email to author Contact us
Abstract

Red-shifted channelrhodopsins (ChRs) are attractive for optogenetic tools. We developed a new type of red-shifted ChRs that utilized noncovalent incorporation of retinal and 3,4-dehydroretinal-based enamine-type Schiff bases and mutated channelopsin, C1C2-K296G. These ChRs exhibited absorption maxima that were shifted 10–30 nm toward longer wavelengths than that of C1C2-ChR regenerated with all-trans-retinal.

Graphical Abstract Fullsize Image
Information related to the author
© 2017 The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top